- Northwestern Medicine Hematopoietic Stem Cell Transplant Program
- Journal of Stem Cell Therapy and Transplantation | HSPC
- Stem cell function and differentiation
This should allow us to use a patient's own cells as gene therapy.
Nakauchi and his collaborators at Stanford are now testing this approach in mice. Explore further. Please sign in to add a comment. Registration is free, and takes less than a minute. Read more.
Northwestern Medicine Hematopoietic Stem Cell Transplant Program
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Representative of at least five experiments. Representative of three independent cultures.
Mean of three independent cultures. Error bars denote s. Medium changes performed at day 7 and day Mean of four independent cultures with fold change relative to unconditioned medium. Representative of four independent cultures. Mean of eight independent cultures. Statistical significance was calculated using t-tests. More information: Adam C. Wilkinson et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation, Nature DOI: Provided by Stanford University Medical Center.
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Journal of Stem Cell Therapy and Transplantation | HSPC
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This type of testing will most likely first have a direct impact on drug development first for cardiac toxicity testing. New areas of study include the effectiveness of using human stem cells that have been programmed into tissue-specific cells to test new drugs. For the testing of new drugs to be accurate, the cells must be programmed to acquire properties of the type of cells targeted by the drug. Techniques to program cells into specific cells continue to be studied.
For instance, nerve cells could be generated to test a new drug for a nerve disease. Tests could show whether the new drug had any effect on the cells and whether the cells were harmed. Embryonic stem cells. These stem cells come from embryos that are three to five days old. At this stage, an embryo is called a blastocyst and has about cells.
These are pluripotent ploo-RIP-uh-tunt stem cells, meaning they can divide into more stem cells or can become any type of cell in the body.
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This versatility allows embryonic stem cells to be used to regenerate or repair diseased tissue and organs. Adult stem cells. These stem cells are found in small numbers in most adult tissues, such as bone marrow or fat. Compared with embryonic stem cells, adult stem cells have a more limited ability to give rise to various cells of the body. Until recently, researchers thought adult stem cells could create only similar types of cells.
For instance, researchers thought that stem cells residing in the bone marrow could give rise only to blood cells. However, emerging evidence suggests that adult stem cells may be able to create various types of cells. For instance, bone marrow stem cells may be able to create bone or heart muscle cells.
This research has led to early-stage clinical trials to test usefulness and safety in people. For example, adult stem cells are currently being tested in people with neurological or heart disease. Adult cells altered to have properties of embryonic stem cells induced pluripotent stem cells. Scientists have successfully transformed regular adult cells into stem cells using genetic reprogramming.
Stem cell function and differentiation
By altering the genes in the adult cells, researchers can reprogram the cells to act similarly to embryonic stem cells. This new technique may allow researchers to use reprogrammed cells instead of embryonic stem cells and prevent immune system rejection of the new stem cells. However, scientists don't yet know whether using altered adult cells will cause adverse effects in humans.
Researchers have been able to take regular connective tissue cells and reprogram them to become functional heart cells. In studies, animals with heart failure that were injected with new heart cells experienced improved heart function and survival time. Perinatal stem cells. Researchers have discovered stem cells in amniotic fluid as well as umbilical cord blood. These stem cells also have the ability to change into specialized cells. Amniotic fluid fills the sac that surrounds and protects a developing fetus in the uterus. Researchers have identified stem cells in samples of amniotic fluid drawn from pregnant women to test for abnormalities — a procedure called amniocentesis.
Embryonic stem cells are obtained from early-stage embryos — a group of cells that forms when a woman's egg is fertilized with a man's sperm in an in vitro fertilization clinic. Because human embryonic stem cells are extracted from human embryos, several questions and issues have been raised about the ethics of embryonic stem cell research.
The National Institutes of Health created guidelines for human stem cell research in The guidelines define embryonic stem cells and how they may be used in research, and include recommendations for the donation of embryonic stem cells. Also, the guidelines state embryonic stem cells from embryos created by in vitro fertilization can be used only when the embryo is no longer needed.
The embryos being used in embryonic stem cell research come from eggs that were fertilized at in vitro fertilization clinics but never implanted in a woman's uterus.